Targeting CD123 in acute myeloid leukemia using a T-cell–directed dual-affinity retargeting platform-Reference-Cited by-同舟云学术

Targeting CD123 in acute myeloid leukemia using a T-cell–directed dual-affinity retargeting platform

Published:2016-01-07 Issue:1 Volume:127 Page:122-131
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Al-Hussaini Muneera¹,Rettig Michael P.¹,Ritchey Julie K.¹,Karpova Darja¹,Uy Geoffrey L.¹,Eissenberg Linda G.¹,Gao Feng²,Eades William C.¹,Bonvini Ezio³,Chichili Gurunadh R.³,Moore Paul A.³,Johnson Syd³,Collins Lynne⁴,DiPersio John F.¹

Affiliation:

1. Division of Oncology, Department of Medicine, and

2. Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO;

3. MacroGenics, Inc., Rockville, MD; and

4. Department of Radiology, Washington University School of Medicine, St. Louis, MO

Abstract

Key Points A novel CD3×CD123 DART agent induces T-cell-target-specific association, activation, and proliferation. The CD3×CD123 DART induces a dose-dependent killing of AML cell lines and primary AML blasts in vitro and in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/1/122/1392190/122.pdf

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