Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila-Reference-Cited by-同舟云学术

Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila

Published:2015-01-08 Issue:2 Volume:125 Page:336-345
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Reitman Zachary J.¹²,Sinenko Sergey A.³,Spana Eric P.⁴,Yan Hai¹²

Affiliation:

1. The Preston Robert Tisch Brain Tumor Center,

2. Department of Pathology, and

3. Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC; and

4. Department of Biology, Duke University, Durham, NC

Abstract

Key Points Homologs to cancer-derived IDH1 and IDH2 mutants produce D-2HG and drive expansion of Drosophila blood cells. In flies, mutant Idh interacts with genes that regulate reduced nicotinamide adenine dinucleotide phosphate, reactive oxygen species, and apoptosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/2/336/1385183/336.pdf

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