The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets-Reference-Cited by-同舟云学术

The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets

Published:2015-01-01 Issue:1 Volume:125 Page:144-154
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Hughes Craig E.¹,Finney Brenda A.¹,Koentgen Frank²,Lowe Kate L.¹,Watson Steve P.¹

Affiliation:

1. Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom; and

2. Ozgene Pty Ltd, Bentley, WA, Australia

Abstract

Key Points Phosphotyrosine-binding capacity of the Syk N-SH2 domain is essential for GPVI and CLEC-2, but not αIIbβ3, activation of mouse platelets. Phosphorylation of Syk on Y519/20, but not of Y346, requires a functional Syk N-terminal SH2 domain.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/1/144/1383003/144.pdf

Reference57 articles.

1. Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins.;Golden;J Cell Biol,1990

2. Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK.;Huang;J Cell Biol,1993

3. Tyrosine phosphorylation and cytoskeletal reorganization in platelets are triggered by interaction of integrin receptors with their immobilized ligands.;Haimovich;J Biol Chem,1993

4. Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets.;Clark;Mol Cell Biol,1993

5. On the role of the platelet membrane skeleton in mediating signal transduction. Association of GP IIb-IIIa, pp60c-src, pp62c-yes, and the p21ras GTPase-activating protein with the membrane skeleton.;Fox;J Biol Chem,1993

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