Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia-Reference-Cited by-同舟云学术

Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia

Published:2015-01-15 Issue:3 Volume:125 Page:525-533
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Spinler Kyle R.¹,Shin Jae-Won¹²,Lambert Michele P.³⁴,Discher Dennis E.¹²

Affiliation:

1. Molecular & Cell Biophysics Laboratory and

2. Graduate Group in Pharmacological Science, University of Pennsylvania, Philadelphia, PA;

3. Divison of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, PA; and

4. Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Abstract

Key Points Myosin-II inhibition (with blebbistatin) and MYH9-RD mutations enhance shear fragmentation to pre/proplatelet sizes. Sustained shear activates normal myosin-II, which then favors division of pre/proplatelets to smaller platelets.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/3/525/1344373/525.pdf

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4. Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice.;Eckly;J Thromb Haemost,2010

5. Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes.;Shin;Proc Natl Acad Sci USA,2011

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