The oncogenic transcription factor IRF4 is regulated by a novel CD30/NF-κB positive feedback loop in peripheral T-cell lymphoma-Reference-Cited by-同舟云学术

The oncogenic transcription factor IRF4 is regulated by a novel CD30/NF-κB positive feedback loop in peripheral T-cell lymphoma

Published:2015-05-14 Issue:20 Volume:125 Page:3118-3127
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Boddicker Rebecca L.¹,Kip N. Sertac¹,Xing Xiaoming¹²,Zeng Yu¹³,Yang Zhi-Zhang⁴,Lee Jeong-Heon⁵,Almada Luciana L.⁶,Elsawa Sherine F.⁶,Knudson Ryan A.¹,Law Mark E.¹,Ketterling Rhett P.¹,Cunningham Julie M.¹,Wu Yanhong¹,Maurer Matthew J.⁷,O’Byrne Megan M.⁷,Cerhan James R.⁷,Slager Susan L.⁷,Link Brian K.⁸,Porcher Julie C.⁴,Grote Deanna M.⁴,Jelinek Diane F.⁴⁹,Dogan Ahmet¹,Ansell Stephen M.⁴,Fernandez-Zapico Martin E.⁶,Feldman Andrew L.¹

Affiliation:

1. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN;

2. Department of Pathology, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China;

3. Department of Pathology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China;

4. Division of Hematology,

5. Epigenomics Translational Program, Center for Individualized Medicine,

6. Schulze Center for Novel Therapeutics, Division of Oncology Research, and

7. Department of Health Sciences Research, Mayo Clinic, Rochester, MN;

8. Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA; and

9. Department of Immunology, Mayo Clinic, Rochester, MN

Abstract

Key Points The NF-κB subunits p52 and RelB increase IRF4 promoter activity and expression in PTCL cells. A positive feedback loop involving CD30, NF-κB, and IRF4 drives PTCL cell proliferation and can be blocked by NF-κB inhibitors.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/20/3118/1385688/3118.pdf

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