Phase 2 study of carfilzomib, thalidomide, and dexamethasone as induction/consolidation therapy for newly diagnosed multiple myeloma

Author:

Sonneveld Pieter1,Asselbergs Emilie1,Zweegman Sonja2,van der Holt Bronno3,Kersten Marie Jose4,Vellenga Edo5,van Marwijk-Kooy Marinus6,Broyl Annemiek1,de Weerdt Okke7,Lonergan Sarah8,Palumbo Antonio9,Lokhorst Henk10

Affiliation:

1. Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands;

2. Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands;

3. HOVON Data Center, Erasmus MC Cancer Institute, Clinical Trial Center, Rotterdam, The Netherlands;

4. Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands;

5. Department of Hematology, University Medical Center Groningen, Groningen, The Netherlands;

6. Department of Hematology, Isala Clinics, Zwolle, The Netherlands;

7. Department of Internal Medicine, St. Antonius Hospital, Nieuwegein, The Netherlands;

8. Department of Hematology, Erasmus University Medical Center, Rotterdam, Netherlands;

9. Myeloma Unit, Division of Hematology, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy; and

10. Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands

Abstract

Key Points KTd is an effective induction and consolidation regimen for transplant-eligible MM patients. The KTd regimen is safe and well tolerated with a notable lack of peripheral neuropathy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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