Differential induction of plasma cells by isoforms of human TACI-Reference-Cited by-同舟云学术

Differential induction of plasma cells by isoforms of human TACI

Published:2015-03-12 Issue:11 Volume:125 Page:1749-1758
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Garcia-Carmona Yolanda¹,Cols Montserrat¹,Ting Adrian T.¹,Radigan Lin¹,Yuk Frank J.²,Zhang Li¹,Cerutti Andrea¹³,Cunningham-Rundles Charlotte¹⁴

Affiliation:

1. Immunology Institute, and

2. Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY;

3. Department of Immunology, Vall d'Hebron University Hospital, Barcelona, Spain; and

4. Departments of Medicine and Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY

Abstract

Key Points Activation of TACI on B cells leads to proliferation, isotype switch, and B-cell survival. Human TACI is produced in 2 isoforms; only the short form is a potent inducer of plasma-cell differentiation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/11/1749/1384283/1749.pdf

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