Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR-domain oligomerization-Reference-Cited by-同舟云学术

Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR-domain oligomerization

Published:2014-12-18 Issue:26 Volume:124 Page:3896-3904
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Avbelj Monika¹²,Wolz Olaf-Oliver³,Fekonja Ota¹,Benčina Mojca¹²,Repič Matej⁴,Mavri Janez⁴,Krüger Jens⁵,Schärfe Charlotta⁵,Delmiro Garcia Magno³,Panter Gabriela¹²,Kohlbacher Oliver⁵,Weber Alexander N. R.³,Jerala Roman¹²

Affiliation:

1. Department of Biotechnology, National Institute of Chemistry, Ljubljana, Slovenia;

2. Centre of Excellence EN-FIST, Ljubljana, Slovenia;

3. Department of Immunology, University of Tübingen, Tübingen, Germany;

4. Laboratory for Biocomputing and Bioinformatics, National Institute of Chemistry, Ljubljana, Slovenia; and

5. Center for Bioinformatics Tübingen, University of Tübingen, Tübingen, Germany

Abstract

Key Points The hyperactive phenotype of lymphoma-associated mutations is caused by increased oligomerization propensity of the MyD88 TIR domain. The TIR domain of mutants interacts with wild-type MyD88, explaining why heterozygous mutation could be sufficient as a driver mutation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/26/3896/1465602/3896.pdf

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