Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells-Reference-Cited by-同舟云学术

Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells

Published:2015-01-08 Issue:2 Volume:125 Page:273-283
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Jing Duohui¹²,Bhadri Vivek A.¹²,Beck Dominik²³,Thoms Julie A. I.²³,Yakob Nurul A.¹²,Wong Jason W. H.²³,Knezevic Kathy²³,Pimanda John E.²³⁴,Lock Richard B.¹²

Affiliation:

1. Children's Cancer Institute Australia for Medical Research,

2. Lowy Cancer Research Centre, and the

3. Prince of Wales Clinical School, University of New South Wales, Sydney, Australia; and

4. Department of Haematology, Prince of Wales Hospital, Sydney, Australia

Abstract

Key Points The glucocorticoid receptor coordinately regulates the antiapoptotic BCL2 and proapoptotic BIM genes in pediatric ALL cells in vivo. GR binding at a novel intronic region is associated with BIM transcription and dexamethasone sensitivity in pediatric ALL cells in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/2/273/1385071/273.pdf

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