The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia-Reference-Cited by-同舟云学术

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

Published:2015-01-01 Issue:1 Volume:125 Page:13-21
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Van der Meulen Joni¹,Sanghvi Viraj²,Mavrakis Konstantinos²,Durinck Kaat¹,Fang Fang³,Matthijssens Filip¹,Rondou Pieter¹,Rosen Monica³,Pieters Tim¹⁴,Vandenberghe Peter⁵,Delabesse Eric⁶,Lammens Tim⁷,De Moerloose Barbara⁷,Menten Björn¹,Van Roy Nadine¹,Verhasselt Bruno⁸,Poppe Bruce¹,Benoit Yves⁷,Taghon Tom⁸,Melnick Ari M.³,Speleman Frank¹,Wendel Hans-Guido²,Van Vlierberghe Pieter¹

Affiliation:

1. Center for Medical Genetics, Ghent University, Ghent, Belgium;

2. Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY;

3. Department of Medicine, Weill Cornell Medical College, New York, NY;

4. Department for Biomedical Molecular Biology, Ghent University, Ghent, Belgium;

5. Centre for Human Genetics, University Hospital Leuven, Leuven, Belgium;

6. INSERM U563, Toulouse, France;

7. Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium; and

8. Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium

Abstract

Key Points The H3K27me3 demethylase UTX is recurrently mutated in male T-ALL and escapes X-inactivation in female T-ALL blasts and normal T cells. The loss of Utx contributes to T-ALL formation in vivo and UTX inactivation confers sensitivity to H3K27me3 inhibition.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/1/13/1383404/13.pdf

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