Growth hormone receptor signaling is dispensable for HSC function and aging-Reference-Cited by-同舟云学术

Growth hormone receptor signaling is dispensable for HSC function and aging

Published:2014-11-13 Issue:20 Volume:124 Page:3076-3080
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Stewart Morag H.¹²,Gutierrez-Martinez Paula¹²,Beerman Isabel¹²,Garrison Brian¹²,Gallagher Emily J.³,LeRoith Derek³,Rossi Derrick J.¹²

Affiliation:

1. Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA;

2. Department of Stem Cell and Regenerative Medicine, Harvard University, Cambridge, MA; and

3. Division of Medicine, Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY

Abstract

Key Points Ghr is specifically expressed on HSCs within the hematopoietic system and is dynamically regulated upon HSC aging and activation. Ghr is dispensable for HSC function.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/20/3076/1381487/3076.pdf

Reference26 articles.

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2. The ageing haematopoietic stem cell compartment.;Geiger;Nat Rev Immunol,2013

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4. Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways.;Taub;Curr Opin Pharmacol,2010

5. Age-associated loss of bone marrow hematopoietic cells is reversed by GH and accompanies thymic reconstitution.;French;Endocrinology,2002

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