Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation-Reference-Cited by-同舟云学术

Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation

Published:2014-10-02 Issue:14 Volume:124 Page:2271-2279
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Yeung Jennifer¹,Tourdot Benjamin E.¹,Fernandez-Perez Pilar¹,Vesci Joanne¹,Ren Jin¹,Smyrniotis Christopher J.²,Luci Diane K.³,Jadhav Ajit³,Simeonov Anton³,Maloney David J.³,Holman Theodore R.²,McKenzie Steven E.¹,Holinstat Michael¹

Affiliation:

1. Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, PA;

2. Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA; and

3. National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, Rockville, MD

Abstract

Key PointsPlatelet 12-LOX modulates FcγRIIa signaling and presents a viable therapeutic target in the prevention of immune-mediated thrombosis. This novel therapeutic approach is supported by pharmacologic inhibition and genetic ablation of 12-LOX in human and mouse platelets.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/14/2271/1380055/2271.pdf

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