ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Author:

Peirs Sofie1,Matthijssens Filip1,Goossens Steven2,Van de Walle Inge3,Ruggero Katia4,de Bock Charles E.5,Degryse Sandrine5,Canté-Barrett Kirsten6,Briot Delphine7,Clappier Emmanuelle7,Lammens Tim8,De Moerloose Barbara8,Benoit Yves8,Poppe Bruce1,Meijerink Jules P.6,Cools Jan5,Soulier Jean7,Rabbitts Terence H.4,Taghon Tom3,Speleman Frank1,Van Vlierberghe Pieter1

Affiliation:

1. Center for Medical Genetics,

2. Flanders Institute for Biotechnology Inflammation Research Center, and

3. Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium;

4. Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, England, United Kingdom;

5. Laboratory for the Molecular Biology of Leukemia, Center for Human Genetics, University of Leuven and Center for the Biology of Disease, Vlaams Instituut voor Biotechnologie, Leuven, Belgium;

6. Department of Pediatric Oncology/Hematology, Erasmus Medical Center, Rotterdam, The Netherlands;

7. Genome Rearrangements and Cancer Laboratory, U462 INSERM, Laboratoire Central d'Hématologie and Institut Universitaire d'Hématologie, Hopital Saint-Louis, Paris, France; and

8. Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium

Abstract

Key Points High levels of the anti-apoptotic factor BCL-2 can be therapeutically exploited by the BH3 mimetic ABT-199 in human T-ALL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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