Thrombocytopenia impairs host defense in gram-negative pneumonia–derived sepsis in mice-Reference-Cited by-同舟云学术

Thrombocytopenia impairs host defense in gram-negative pneumonia–derived sepsis in mice

Published:2014-12-11 Issue:25 Volume:124 Page:3781-3790
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

de Stoppelaar Sacha F.¹²,van ’t Veer Cornelis¹²,Claushuis Theodora A. M.¹²,Albersen Bregje J. A.¹²,Roelofs Joris J. T. H.³,van der Poll Tom¹²⁴

Affiliation:

1. Center for Infection and Immunity Amsterdam,

2. Center for Experimental and Molecular Medicine,

3. Department of Pathology, and

4. Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Abstract

Key Points Severe thrombocytopenia is associated with a strongly impaired host defense during pneumonia-derived Klebsiella pneumoniae sepsis. Platelet counts between 5 and 13 × 109/L of normal prevent bleeding and confer protection against distant organ damage during gram-negative sepsis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/25/3781/1465307/3781.pdf

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