Reed-Sternberg cell–derived lymphotoxin-α activates endothelial cells to enhance T-cell recruitment in classical Hodgkin lymphoma-Reference-Cited by-同舟云学术

Reed-Sternberg cell–derived lymphotoxin-α activates endothelial cells to enhance T-cell recruitment in classical Hodgkin lymphoma

Published:2014-11-06 Issue:19 Volume:124 Page:2973-2982
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Fhu Chee Wai¹,Graham Anne M.²,Yap Celestial T.¹³,Al-Salam Suhail⁴,Castella Antonio⁵,Chong Siew Meng⁶,Lim Yaw-Chyn¹³⁶⁷

Affiliation:

1. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;

2. School of Medical Sciences, School of Life Sciences, University of Bradford, Bradford, United Kingdom;

3. National University Cancer Institute, Singapore, Singapore;

4. Department of Pathology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates;

5. Tawam Hospital, Pathology Laboratories, Hematology Division, Al Ain, United Arab Emirates; and

6. Department of Pathology and

7. Immunology Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

Abstract

Key Points HRS cell-derived LTα activates the endothelium to enhance T-cell recruitment. COX/NF-κB/AP1 pathways act in concert to regulate LTα production.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/19/2973/1381526/2973.pdf

Reference64 articles.

1. Tumor microenvironment and mitotic checkpoint are key factors in the outcome of classic Hodgkin lymphoma.;Sánchez-Aguilera;Blood,2006

2. The biology of Hodgkin’s lymphoma.;Küppers;Nat Rev Cancer,2009

3. Infiltration of Th1 and Th2 lymphocytes around Hodgkin and Reed-Sternberg (H&RS) cells in Hodgkin disease: Relation with expression of CXC and CC chemokines on H&RS cells.;Ohshima;Int J Cancer,2002

4. Hodgkin and Reed-Sternberg cells in Hodgkin’s disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.;Kanzler;J Exp Med,1996

5. Hodgkin and reed-sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription.;Marafioti;Blood,2000

Cited by 33 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The biology of classical Hodgkin lymphoma;Seminars in Hematology;2024-05

2. Role of CD68 in the tumor immune microenvironment in Hodgkin’s lymphoma;Expert Review of Clinical Immunology;2023-12-12

3. Potential Associations between Vascular Biology and Hodgkin’s Lymphoma: An Overview;Cancers;2023-11-06

4. Exome-wide association study reveals 7 functional variants associated with ex-vivo drug response in acute myeloid leukaemia patients;2023-08-04

5. Current and Emerging Approaches to Study Microenvironmental Interactions and Drug Activity in Classical Hodgkin Lymphoma;Cancers;2022-05-14