Somatic mutations identify a subgroup of aplastic anemia patients who progress to myelodysplastic syndrome

Author:

Kulasekararaj Austin G.12,Jiang Jie12,Smith Alexander E.12,Mohamedali Azim M.12,Mian Syed1,Gandhi Shreyans2,Gaken Joop1,Czepulkowski Barbara2,Marsh Judith C. W.12,Mufti Ghulam J.12

Affiliation:

1. Department of Haematological Medicine, King’s College London School of Medicine, London, United Kingdom; and

2. Department of Haematology, King’s College Hospital, London, United Kingdom

Abstract

Key Points Acquired mutations of myeloid-related genes are present in a proportion of AA patients. Somatic mutations in AA predict higher risk of transformation to MDS.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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