Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1-Reference-Cited by-同舟云学术

Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1

Published:2014-12-11 Issue:25 Volume:124 Page:3748-3757
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Umezu Tomohiro¹²,Tadokoro Hiroko³,Azuma Kenko⁴²,Yoshizawa Seiichiro⁴,Ohyashiki Kazuma¹⁴,Ohyashiki Junko H.²

Affiliation:

1. Department of Molecular Science, Tokyo Medical University, Tokyo, Japan;

2. Institute of Medical Science, Tokyo Medical University, Tokyo, Japan

3. Department of Pharmaceutical Health Care and Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan;

4. Department of Hematology and

Abstract

Key Points We established hypoxia-resistant cells that can mimic in vivo conditions of hypoxic bone marrow. Exosomal miR-135b derived from these cell lines enhanced endothelial tube formation under hypoxia via the HIF-FIH signaling pathway.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/25/3748/1465239/3748.pdf

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