Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade-Reference-Cited by-同舟云学术

Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade

Published:2015-04-23 Issue:17 Volume:125 Page:2693-2703
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Magwenzi Simbarashe¹,Woodward Casey¹,Wraith Katie S.¹,Aburima Ahmed¹,Raslan Zaher¹,Jones Huw¹,McNeil Catriona¹,Wheatcroft Stephen²,Yuldasheva Nadira²,Febbriao Maria³,Kearney Mark²,Naseem Khalid M.¹

Affiliation:

1. Centre for Cardiovascular and Metabolic Research, Hull-York Medical School, Thrombosis Research Laboratory (013/014), University of Hull, Hull, United Kingdom;

2. Division of Cardiovascular and Diabetes Research, Leeds Multidisciplinary Cardiovascular Research Centre, LIGHT Laboratories, University of Leeds, Leeds, United Kingdom; and

3. School of Dentistry, University of Alberta, Edmonton, AB, Canada

Abstract

Key Points oxLDL binds platelet CD36 to stimulate tyrosine kinase– and PKC-dependent activation of NOX2 and generation of ROS. oxLDL- and hyperlipidemia-induced ROS mediate platelet desensitization to inhibitory cGMP signaling to facilitate platelet activation and thrombus formation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/17/2693/1385390/2693.pdf

Reference48 articles.

1. The nitric oxide and cGMP signal transduction system: regulation and mechanism of action.;Schmidt;Biochim Biophys Acta,1993

2. Platelet function in hyperlipoproteinemia.;Carvalho;N Engl J Med,1974

3. Increased levels of soluble P-selectin in hypercholesterolemic patients.;Davì;Circulation,1998

4. Increased platelet-fibrinogen interaction in patients with hypercholesterolemia and hypertriglyceridemia.;Pawlowska;Atherosclerosis,1993

5. LDL from obese patients with the metabolic syndrome show increased lipid peroxidation and activate platelets.;Colas;Diabetologia,2011

Cited by 133 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Redox regulation of platelet function and thrombosis;Journal of Thrombosis and Haemostasis;2024-06

2. Effects of PCSK9 on thrombosis and haemostasis in a variety of metabolic states: Lipids and beyond (Review);International Journal of Molecular Medicine;2024-05-10

3. Platelets as an inter‐player between hyperlipidaemia and atherosclerosis;Journal of Internal Medicine;2024-05-05

4. NADPH-oxidases as potential pharmacological targets for thrombosis and depression comorbidity;Redox Biology;2024-04

5. Targeting Cysteine Oxidation in Thrombotic Disorders;Antioxidants;2024-01-09