Gq-mediated Akt translocation to the membrane: a novel PIP3-independent mechanism in platelets-Reference-Cited by-同舟云学术

Gq-mediated Akt translocation to the membrane: a novel PIP3-independent mechanism in platelets

Published:2015-01-01 Issue:1 Volume:125 Page:175-184
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Badolia Rachit¹²,Manne Bhanu Kanth¹²,Dangelmaier Carol¹²,Chernoff Jonathan³,Kunapuli Satya P.¹²

Affiliation:

1. Department of Physiology,

2. Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA; and

3. Fox Chase Cancer Center, Temple Health, Philadelphia, PA

Abstract

Key Points There is a novel PIP3-independent and Gq-dependent Akt translocation mechanism in the platelets. PAK constitutively associates with Akt, and possibly mediates its membrane translocation independently of PIP3.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/1/175/1383648/175.pdf

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4. PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses.;Dangelmaier;Thromb Haemost,2014

5. PDK1 regulates platelet activation and arterial thrombosis.;Chen;Blood,2013

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