p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency-Reference-Cited by-同舟云学术

p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency

Published:2015-04-09 Issue:15 Volume:125 Page:2344-2348
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Belle Jad I.¹²,Langlais David²³,Petrov Jessica C.¹²,Pardo Mercedes⁴,Jones Russell G.¹⁵,Gros Philippe²³⁵,Nijnik Anastasia¹²

Affiliation:

1. Department of Physiology,

2. Complex Traits Group, and

3. Department of Biochemistry, McGill University, Montreal, QC, Canada;

4. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom; and

5. The Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada

Abstract

Key Points Developmental defects and impairment in lymphopoiesis in Mysm1-knockout mice are the result of p53 activation. Loss of hematopoietic stem cell function and bone marrow failure in Mysm1-knockout mice are the result of p53 activation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/15/2344/1383973/2344.pdf

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