Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms-Reference-Cited by-同舟云学术

Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms

Published:2015-01-08 Issue:2 Volume:125 Page:327-335
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Chen Edwin¹,Schneider Rebekka K.¹,Breyfogle Lawrence J.¹,Rosen Emily A.¹,Poveromo Luke¹,Elf Shannon¹,Ko Amy¹,Brumme Kristina¹,Levine Ross²,Ebert Benjamin L.¹³,Mullally Ann¹³^ORCID

Affiliation:

1. Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA;

2. Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY; and

3. Broad Institute, Cambridge, MA

Abstract

Key Points Tet2 loss of function confers a strong functional competitive advantage to Jak2V617F-mutant hematopoietic stem cells. Jak2V617F expression and Tet2 loss generate distinct and nonoverlapping transcriptional programs in hematopoietic stem cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/2/327/1385925/327.pdf

Reference41 articles.

1. Clonal architecture of secondary acute myeloid leukemia.;Walter;N Engl J Med,2012

2. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.;Cancer Genome Atlas Research Network;N Engl J Med,2013

3. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2.;Nangalia;N Engl J Med,2013

4. New mutations and pathogenesis of myeloproliferative neoplasms.;Vainchenker;Blood,2011

5. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.;Baxter;Lancet,2005

Cited by 85 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Increased CXCL10 (IP-10) is associated with advanced myeloproliferative neoplasms and its loss dampens erythrocytosis in mouse models;Experimental Hematology;2024-07

2. Jak2V617F Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms;Cancer Discovery;2024-01-12

3. SRSF2 mutation reduces polycythemia and impairs hematopoietic progenitor functions in JAK2V617F-driven myeloproliferative neoplasm;Blood Cancer Journal;2023-11-27

4. Noncoding rules of survival: epigenetic regulation of normal and malignant hematopoiesis;Frontiers in Molecular Biosciences;2023-10-31

5. STING activation in TET2-mutated hematopoietic stem/progenitor cells contributes to the increased self-renewal and neoplastic transformation;Leukemia;2023-10-10