Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres-Reference-Cited by-同舟云学术

Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres

Published:2014-11-20 Issue:22 Volume:124 Page:3237-3240
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wang Jianwei¹²,Lu Xin³,Sakk Vadim⁴,Klein Christoph A.³⁵,Rudolph Karl Lenhard¹²

Affiliation:

1. Leibniz Institute of Age Research, Fritz Lipmann Institute e.V., Jena, Germany;

2. Research Group on Molecular Aging, Faculty of Medicine, Friedrich-Schiller-University, Jena, Germany;

3. Experimental Medicine and Therapy Research, University Regensburg, Regensburg, Germany;

4. Cooperation Group: Leibniz Institute for Age Research and University Ulm, Ulm, Germany; and

5. Fraunhofer-Institut für Toxikologie und Experimentelle Medizin, Project Group Personalized Tumor Therapy, Regensburg, Germany

Abstract

Key Points DNA damage induced by telomere shortening resides in most quiescent HSCs. Senescence and apoptosis compromise the activation of HSCs with dysfunctional telomeres.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/22/3237/1465094/3237.pdf

Reference21 articles.

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4. Telomere diseases.;Calado;N Engl J Med,2009

5. Telomeres, stem cells, and hematology.;Lansdorp;Blood,2008

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