Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells-Reference-Cited by-同舟云学术

Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells

Published:2014-11-20 Issue:22 Volume:124 Page:3241-3249
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Romain Gabrielle¹,Senyukov Vladimir²,Rey-Villamizar Nicolas³,Merouane Amine³,Kelton William⁴,Liadi Ivan¹,Mahendra Ankit¹,Charab Wissam⁴,Georgiou George⁴,Roysam Badrinath³,Lee Dean A.²,Varadarajan Navin¹

Affiliation:

1. Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX;

2. Division of Pediatrics, University of Texas M.D. Anderson Cancer Center, Houston, TX;

3. Department of Electrical Engineering, University of Houston, Houston, TX; and

4. Department of Chemical Engineering, Institute for Cell and Molecular Biology, University of Texas, Austin, TX

Abstract

Key Points Fc-engineered mAb promotes NK cell ADCC via better activation, serial killing, and kinetic boosting at higher target cell densities. Enhanced target killing also increased frequency of NK cell apoptosis, but this effect is donor-dependent.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/22/3241/1464787/3241.pdf

Reference45 articles.

1. Monoclonal antibodies: versatile platforms for cancer immunotherapy.;Weiner;Nat Rev Immunol,2010

2. Boosting ADCC and CDC activity by Fc engineering and evaluation of antibody effector functions.;Kellner;Methods,2014

3. Fc optimization of therapeutic antibodies enhances their ability to kill tumor cells in vitro and controls tumor expansion in vivo via low-affinity activating Fcgamma receptors.;Stavenhagen;Cancer Res,2007

4. Aglycosylated IgG variants expressed in bacteria that selectively bind FcgammaRI potentiate tumor cell killing by monocyte-dendritic cells.;Jung;Proc Natl Acad Sci USA,2010

5. The impact of Fc engineering on an anti-CD19 antibody: increased Fcgamma receptor affinity enhances B-cell clearing in nonhuman primates.;Zalevsky;Blood,2009

Cited by 85 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Mature tertiary lymphoid structures: important contributors to anti-tumor immune efficacy;Frontiers in Immunology;2024-07-04

2. Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions;PLOS Pathogens;2024-06-20

3. Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling;Nature Cancer;2024-05-15

4. Natural Killer Cell Infiltration in Prostate Cancers Predict Improved Patient Outcomes;Prostate Cancer and Prostatic Diseases;2024-02-28

5. Decoding the mechanisms of chimeric antigen receptor (CAR) T cell-mediated killing of tumors: insights from granzyme and Fas inhibition;Cell Death & Disease;2024-02-02