JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model-Reference-Cited by-同舟云学术

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model

Published:2014-11-13 Issue:20 Volume:124 Page:3092-3100
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Degryse Sandrine¹²,de Bock Charles E.¹²,Cox Luk¹²,Demeyer Sofie¹²,Gielen Olga¹²,Mentens Nicole¹²,Jacobs Kris¹²,Geerdens Ellen¹²,Gianfelici Valentina³,Hulselmans Gert²,Fiers Mark¹²,Aerts Stein²,Meijerink Jules P.⁴,Tousseyn Thomas⁵,Cools Jan¹²

Affiliation:

1. Vlaams Instituut voor Biotechnologie Center for the Biology of the Disease, Leuven, Belgium;

2. Katholieke Universiteit Leuven Center for Human Genetics, Leuven, Belgium;

3. Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy;

4. Department of Pediatric Oncology/Hematology, Erasmus University Medical Center Rotterdam-Sophia Children’s Hospital, Rotterdam, The Netherlands; and

5. Department of Pathology, Universitaire Ziekenhuizen, Leuven, Belgium

Abstract

Key Points JAK3 pseudokinase mutants require JAK1 for their transforming potential. JAK3 mutants cause T-ALL in a mouse bone marrow transplant model and respond to tofacitinib, a JAK3-selective inhibitor.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/20/3092/1381731/3092.pdf

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