Exploiting the kinetic interplay between GPIbα–VWF binding interfaces to regulate hemostasis and thrombosis-Reference-Cited by-同舟云学术

Exploiting the kinetic interplay between GPIbα–VWF binding interfaces to regulate hemostasis and thrombosis

Published:2014-12-11 Issue:25 Volume:124 Page:3799-3807
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Chen Jianchung¹,Zhou Hairu¹,Diacovo Alexander¹,Zheng X. Long²,Emsley Jonas³,Diacovo Thomas G.¹⁴

Affiliation:

1. Department of Pediatrics, Columbia University Medical Center, New York, NY;

2. Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA;

3. Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham, United Kingdom; and

4. Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY

Abstract

Key PointsGPIbα–VWF-A1 bond kinetics regulates platelet–VWF interactions and can be altered to correct defects in hemostasis or prevent thrombosis. Targeting a distinct GPIbα−VWF-A1 binding interface may offer a unique therapeutic approach to reducing platelet-driven thrombosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/25/3799/1465396/3799.pdf

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