Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone-Reference-Cited by-同舟云学术

Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone

Published:2014-11-13 Issue:20 Volume:124 Page:3141-3150
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Leblanc Raphael¹,Lee Sue-Chin²,David Marion³,Bordet Jean-Claude⁴,Norman Derek D.²,Patil Renukadevi⁵,Miller Duane⁵,Sahay Debashish¹,Ribeiro Johnny¹,Clézardin Philippe¹,Tigyi Gabor J.²,Peyruchaud Olivier¹

Affiliation:

1. Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1033, Université Claude Bernard Lyon 1, Faculté de Médecine Lyon Est, Lyon, France;

2. Department of Physiology, University of Tennessee Health Science Center, Memphis, TN;

3. Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1037, Université de Toulouse III, Institut Claudius Regaud, Toulouse, France;

4. EA4174, Université Claude Bernard Lyon 1, Faculté de Médecine Lyon Est, Lyon, France; and

5. Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN

Abstract

Key Points ATX stored in α-granules of resting platelets is secreted upon tumor cell-induced aggregation leading to prometastatic LPA production. Nontumoral ATX promotes early bone colonization by breast cancer cells and contributes to the progression of skeletal metastases.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/20/3141/1381221/3141.pdf

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