Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo

Author:

Iqbal Asif J.1,McNeill Eileen23,Kapellos Theodore S.1,Regan-Komito Daniel1,Norman Sophie4,Burd Sarah1,Smart Nicola4,Machemer Daniel E. W.5,Stylianou Elena6,McShane Helen6,Channon Keith M.23,Chawla Ajay7,Greaves David R.1

Affiliation:

1. Sir William Dunn School of Pathology, University of Oxford, United Kingdom;

2. Division of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom;

3. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom;

4. Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom;

5. Genentech, South San Francisco, CA;

6. Jenner Institute, University of Oxford, Oxford, United Kingdom; and

7. Cardiovascular Research Institute, Departments of Physiology and Medicine, University of California San Francisco, CA

Abstract

Key Points CD68-GFP reporter mice show GFP transgene expression in both monocytes and tissue resident macrophage populations. Adoptively transferred CD68-GFP monocytes maintain GFP expression after recruitment in an ongoing inflammatory response.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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