TAILS N-terminomics of human platelets reveals pervasive metalloproteinase-dependent proteolytic processing in storage-Reference-Cited by-同舟云学术

TAILS N-terminomics of human platelets reveals pervasive metalloproteinase-dependent proteolytic processing in storage

Published:2014-12-18 Issue:26 Volume:124 Page:e49-e60
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Prudova Anna¹²,Serrano Katherine¹³^ORCID,Eckhard Ulrich¹²^ORCID,Fortelny Nikolaus¹⁴^ORCID,Devine Dana V.¹³⁴,Overall Christopher M.¹²⁴

Affiliation:

1. Centre for Blood Research, and

2. Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC, Canada;

3. Canadian Blood Services, Vancouver, BC, Canada; and

4. Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada

Abstract

Key Points TAILS proteomics identified 2938 human platelet proteins, pervasive proteolytic processing, and precise proteolytic cleavage sites in stored platelets. During storage, metalloproteinases were predominantly involved in proteolytic processing, while other proteinases were mainly involved in degradation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/26/e49/1466410/e49.pdf

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