Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites

Author:

Smith Clare M.12,Jerkovic Ante3,Puy Hervé456,Winship Ingrid78,Deybach Jean-Charles45,Gouya Laurent56,van Dooren Giel9,Goodman Christopher Dean10,Sturm Angelika10,Manceau Hana45,McFadden Geoffrey Ian10,David Peter11,Mercereau-Puijalon Odile11,Burgio Gaétan3,McMorran Brendan J.3,Foote Simon J.312

Affiliation:

1. Menzies Research Institute Tasmania and

2. School of Medicine, University of Tasmania, Hobart, TAS, Australia;

3. Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia;

4. Centre Français des Porphyries, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, France;

5. Centre de Recherche sur l’Inflammation, INSERM U1149, Paris, France;

6. Groupe d′Excellence, Pôle de Recherche et d'Enseignement Supérieur, Sorbonne Paris-Cité, Paris, France;

7. Department of Medicine, University of Melbourne, Melbourne, VIC, Australia;

8. Office of Research, Royal Melbourne Hospital, Parkville, VIC, Australia;

9. Research School of Biology, Australian National University, Canberra, ACT, Australia;

10. School of Botany, University of Melbourne, Parkville, VIC, Australia;

11. Institut Pasteur, Unité d’Immunologie Moléculaire des Parasites, Centre Nationale de la Recherche Scientifique, Unite de Recherche Associé 2581, Paris, France; and

12. The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia

Abstract

Key PointsMalarial parasite growth is impeded in erythropoietic protoporphyric erythrocytes because of decreased host cell ferrochelatase activity. A ferrochelatase competitive inhibitor prevents the growth of malarial parasites in normal red cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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