Jun-regulated genes promote interaction of diffuse large B-cell lymphoma with the microenvironment

Author:

Blonska Marzenna12,Zhu Yifan1,Chuang Hubert H.3,You M. James24,Kunkalla Kranthi5,Vega Francisco5,Lin Xin126

Affiliation:

1. Department of Molecular and Cellular Oncology,

2. Center for Inflammation and Cancer,

3. Department of Nuclear Medicine, and

4. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX;

5. Department of Pathology, Sylvester Cancer Center, University of Miami, Miami, FL; and

6. Cancer Biology Program, The University of Texas Graduate School of Biomedical Sciences, Houston, TX

Abstract

Key Points Elevated Jun signaling promotes lymphoma growth and dissemination to extranodal sites. Jun-regulated genes mediate the interaction of malignant cells with stromal cells and adhesion to extracellular matrix proteins.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference50 articles.

1. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling.;Alizadeh;Nature,2000

2. Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells.;Davis;J Exp Med,2001

3. Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling.;Lam;Clin Cancer Res,2005

4. A loss-of-function RNA interference screen for molecular targets in cancer.;Ngo;Nature,2006

5. Oncogenic CARD11 mutations in human diffuse large B cell lymphoma.;Lenz;Science,2008

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