The role of galectin-3 and galectin-3–binding protein in venous thrombosis

Author:

DeRoo Elise P.1,Wrobleski Shirley K.1,Shea Evelyn M.1,Al-Khalil Ramsey K.1,Hawley Angela E.1,Henke Peter K.1,Myers Daniel D.1,Wakefield Thomas W.1,Diaz Jose A.1

Affiliation:

1. Department of Surgery, Section of Vascular Surgery, Conrad Jobst Vascular Research Laboratories, and Unit for Laboratory Animal Research, University of Michigan, Ann Arbor, MI

Abstract

Key Points We determined the location of gal3bp and gal3 and their role in promoting VT and leukocyte/endothelial cell interactions for the first time. Gal3bp and gal3 have the potential to be used as targets for future VT therapies.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference39 articles.

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5. Carbohydrate-binding protein 35 (Mac-2), a laminin-binding lectin, forms functional dimers using cysteine 186.;Woo;J Biol Chem,1991

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