Murine pre–B-cell ALL induces T-cell dysfunction not fully reversed by introduction of a chimeric antigen receptor-Reference-Cited by-同舟云学术

Murine pre–B-cell ALL induces T-cell dysfunction not fully reversed by introduction of a chimeric antigen receptor

Published:2018-11-01 Issue:18 Volume:132 Page:1899-1910
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Qin Haiying¹,Ishii Kazusa¹,Nguyen Sang¹,Su Paul P.¹²,Burk Chad R.¹²,Kim Bong-Hyun³⁴,Duncan Brynn B.¹,Tarun Samikasha¹,Shah Nirali N.¹,Kohler M. Eric¹,Fry Terry J.¹^ORCID

Affiliation:

1. Hematologic Malignancies Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;

2. Howard Hughes Medical Institute, Chevy Chase, MD;

3. Center for Cancer Research Collaborative Bioinformatics Resource, Frederick National Laboratory for Cancer Research, Frederick, MD; and

4. Leidos Biomedical Research, Inc., Frederick, MD

Abstract

Key Points Pre–B-cell ALL induces T-cell dysfunction in vivo, mediated in part by a non–T-cell receptor–linked mechanism. Prior exposure of T cells to pre–B-cell ALL in vivo impairs subsequent functionality of CAR-expressing T cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/132/18/1899/1469566/blood815548.pdf

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