A Caenorhabditis elegans–based assay recognizes immunoglobulin light chains causing heart amyloidosis-Reference-Cited by-同舟云学术

A Caenorhabditis elegans–based assay recognizes immunoglobulin light chains causing heart amyloidosis

Published:2014-06-05 Issue:23 Volume:123 Page:3543-3552
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Diomede Luisa¹,Rognoni Paola²,Lavatelli Francesca²,Romeo Margherita¹,del Favero Elena³,Cantù Laura³,Ghibaudi Elena⁴,di Fonzo Andrea²,Corbelli Alessandro⁵⁶,Fiordaliso Fabio⁵,Palladini Giovanni²⁷,Valentini Veronica²,Perfetti Vittorio⁸,Salmona Mario¹,Merlini Giampaolo²⁷

Affiliation:

1. Department of Molecular Biochemistry and Pharmacology, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto di Ricerche Farmacologiche “Mario Negri,” Milan, Italy;

2. Amyloid Research and Treatment Center, Foundation Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy;

3. Department of Medical Biotechnology and Translational Medicine University of Milan, Laboratorio Interdisciplinare Tecnologie Avanzate, Segrate, Italy;

4. Department of Chemistry, University of Turin, Turin, Italy;

5. Bio-imaging Unit, Department of Cardiovascular Research, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto di Ricerche Farmacologiche “Mario Negri,” Milan, Italy;

6. Renal Research Laboratory, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Cà Granda Ospedale Maggiore Policlinico and Fondazione D’Amico per la Ricerca sulle Malattie Renali, Milan, Italy;

7. Department of Molecular Medicine, University of Pavia, Italy; and

8. Medical Oncology Unit, Foundation Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy

Abstract

Key PointsC elegans specifically recognizes cardiotoxic LCs as toxicants. This is an innovative model for studying the heart-specific toxicity of amyloidogenic LCs and developing new therapeutic strategies.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/23/3543/1378079/3543.pdf

Reference49 articles.

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4. New criteria for response to treatment in immunoglobulin light chain amyloidosis based on free light chain measurement and cardiac biomarkers: impact on survival outcomes.;Palladini;J Clin Oncol,2012

5. Circulating amyloidogenic free light chains and serum N-terminal natriuretic peptide type B decrease simultaneously in association with improvement of survival in AL.;Palladini;Blood,2006

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