TBLR1 fuses to retinoid acid receptor α in a variant t(3;17)(q26;q21) translocation of acute promyelocytic leukemia-Reference-Cited by-同舟云学术

TBLR1 fuses to retinoid acid receptor α in a variant t(3;17)(q26;q21) translocation of acute promyelocytic leukemia

Published:2014-08-07 Issue:6 Volume:124 Page:936-945
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Chen Yirui¹,Li Shouyun¹,Zhou Chunlin²,Li Chengwen³,Ru Kun³,Rao Qing¹,Xing Haiyan¹,Tian Zheng¹,Tang Kejing¹,Mi Yingchang²,Wang Baohong⁴,Wang Min¹,Wang Jianxiang¹²

Affiliation:

1. State Key Laboratory of Experimental Hematology,

2. Department of Clinical Hematology, and

3. Department of Hematopathology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China; and

4. Department of Clinical Hematology, Weifang People’s Hospital, Shandong, China

Abstract

Key Points A novel RARα fusion gene, TBLR1-RARα, was found in rare cases of APL with t(3;17) chromosomal translocation. TBLR1-RARα exhibited diminished transcriptional activity by recruiting more corepressors compared with RARα.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/6/936/1382499/936.pdf

Reference47 articles.

1. Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia.;Melnick;Blood,1999

2. Acute promyelocytic leukemia: from highly fatal to highly curable.;Wang;Blood,2008

3. Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.;Chen;EMBO J,1993

4. The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion.;Redner;Blood,1996

5. Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia.;Wells;Nat Genet,1997

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