A meta-analysis of genome-wide association studies identifies ORM1 as a novel gene controlling thrombin generation potential

Author:

Rocanin-Arjo Ares12,Cohen William34,Carcaillon Laure56,Frère Corinne4,Saut Noémie34,Letenneur Luc7,Alhenc-Gelas Martine8,Dupuy Anne-Marie9,Bertrand Marion10,Alessi Marie-Christine34,Germain Marine12,Wild Philipp S.111213,Zeller Tanja1314,Cambien Francois12,Goodall Alison H.15,Amouyel Philippe1617,Scarabin Pierre-Yves56,Trégouët David-Alexandre12,Morange Pierre-Emmanuel34,

Affiliation:

1. Pierre and Marie Curie University, INSERM, UMR_S 1166, Paris, France;

2. ICAN Institute for Cardiometabolism And Nutrition, Pierre and Marie Curie University, Paris, France;

3. Nutrition Obesity and Risk of Thrombosis, Aix-Marseille University, INSERM UMR_S 1062, Marseille, France;

4. Laboratory of Haematology, La Timone Hospital, Marseille, France;

5. CESP Centre for research in Epidemiology and Population Health, UMR-S1018, Hormones and Cardiovascular Disease, INSERM, Villejuif, France;

6. Université Paris Sud 11, Kremlin-Bicêtre, France;

7. INSERM U897, Bordeaux, France and University Bordeaux, ISPED, Bordeaux, France;

8. Service d’Hématologie Biologique, Hôpital Européen G Pompidou, Paris, France;

9. Hôpital La Colombière, INSERM UMR_S 1061, Montpellier, France;

10. Pierre and Marie Curie University, INSERM UMR_S 708, Paris, France;

11. Center for Thrombosis and Hemostasis,

12. Department of Medicine 2, and

13. German Center for Cardiovascular Research (DZHK), University Medical Center Mainz, Mainz, Germany;

14. Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany;

15. Department of Cardiovascular Sciences, University of Leicester and Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom;

16. Institut Pasteur de Lille, Université de Lille Nord de France, INSERM UMR_S 744, Lille, France; and

17. Centre Hospitalier Régional Universitaire de Lille, Lille, France

Abstract

Key PointsGenetic variations at the ORM1 locus and concentrations of the encoded protein associate with thrombin generation. These findings may guide the development of novel antithrombotic treatments.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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