Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease-Reference-Cited by-同舟云学术

Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease

Published:2014-06-12 Issue:24 Volume:123 Page:3818-3827
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Chen Grace¹,Zhang Dachuan¹,Fuchs Tobias A.²,Manwani Deepa³,Wagner Denisa D.²⁴,Frenette Paul S.¹

Affiliation:

1. Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY;

2. Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA, and Department of Pediatrics, Harvard Medical School, Boston, MA;

3. Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY; and

4. Division of Hematology/Oncology, Boston Children’s Hospital, Boston, MA

Abstract

Key Points NETs are present and pathogenic in sickle cell disease. Plasma heme and proinflammatory cytokines collaborate to activate release of NETs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/24/3818/1377284/3818.pdf

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4. Neutrophil activation in sickle cell disease.;Lard;J Leukoc Biol,1999

5. Red blood cells, platelets and polymorphonuclear neutrophils of patients with sickle cell disease exhibit oxidative stress that can be ameliorated by antioxidants.;Amer;Br J Haematol,2006

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