Cell of origin of transformed follicular lymphoma-Reference-Cited by-同舟云学术

Cell of origin of transformed follicular lymphoma

Published:2015-10-29 Issue:18 Volume:126 Page:2118-2127
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kridel Robert¹²,Mottok Anja¹²,Farinha Pedro¹²,Ben-Neriah Susana¹,Ennishi Daisuke¹,Zheng Yvonne¹,Chavez Elizabeth A.¹,Shulha Hennady P.¹,Tan King¹,Chan Fong Chun¹,Boyle Merrill¹,Meissner Barbara¹,Telenius Adele¹,Sehn Laurie H.¹³,Marra Marco A.⁴⁵,Shah Sohrab P.²⁶,Steidl Christian¹²,Connors Joseph M.¹³,Scott David W.¹³,Gascoyne Randy D.¹²

Affiliation:

1. Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, BC, Canada;

2. Department of Pathology and Laboratory Medicine, and

3. Department of Medicine, University of British Columbia, Vancouver, BC, Canada;

4. Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada;

5. Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada; and

6. Molecular Oncology, BC Cancer Agency, Vancouver, BC, Canada

Abstract

Key Points TFL is most commonly of the germinal center B-cell-like phenotype, but a significant minority of cases is of the ABC phenotype (16%). The absence of BCL2 translocation in FL at diagnosis is associated with transformation into ABC-like large cell lymphoma.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/18/2118/1389627/2118.pdf

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