Enhanced phosphocholine metabolism is essential for terminal erythropoiesis

Author:

Huang Nai-Jia1,Lin Ying-Cing2,Lin Chung-Yueh13,Pishesha Novalia14,Lewis Caroline A.1,Freinkman Elizaveta1,Farquharson Colin5,Millán José Luis67,Lodish Harvey134

Affiliation:

1. Whitehead Institute for Biomedical Research, Cambridge, MA;

2. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA;

3. Department of Biology and

4. Department of Biological Engineering, MIT, Cambridge, MA;

5. The Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom;

6. Sanford Children’s Health Research Center, La Jolla, CA; and

7. Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA

Abstract

Key PointsPHOSPHO1 regulates phosphocholine metabolism, ATP production, and amino acid supply during erythropoiesis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference38 articles.

1. Disorders of red cell membrane;An;Br J Haematol,2008

2. Red cell membrane disorders in the Japanese population: clinical, biochemical, electron microscopic, and genetic studies;Yawata;Int J Hematol,1994

3. Red cell membrane disorders;Saraya;J Assoc Physicians India,1994

4. Red cell membrane lipids in hemoglobinopathies;Kuypers;Curr Mol Med,2008

5. Membrane lipid alterations in hemoglobinopathies;Kuypers;Hematology Am Soc Hematol Educ Program,2007

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