Genetic and epigenetic evolution as a contributor to WT1-mutant leukemogenesis-Reference-Cited by-同舟云学术

Genetic and epigenetic evolution as a contributor to WT1-mutant leukemogenesis

Published:2018-09-20 Issue:12 Volume:132 Page:1265-1278
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Pronier Elodie¹²,Bowman Robert L.¹²,Ahn Jihae¹²,Glass Jacob¹²,Kandoth Cyriac¹²³⁴,Merlinsky Tiffany R.¹²,Whitfield Justin T.¹²,Durham Benjamin H.¹,Gruet Antoine²,Hanasoge Somasundara Amritha Varshini¹²^ORCID,Rampal Raajit¹²,Melnick Ari⁵,Koche Richard P.²,Taylor Barry S.¹²³⁴,Levine Ross L.¹²⁵⁶⁷

Affiliation:

1. Human Oncology and Pathogenesis Program,

2. Center for Epigenetics Research,

3. Department of Epidemiology and Biostatistics, and

4. Marie-Josee and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY;

5. Division of Hematology/Oncology, Weill Cornell Medical College, Cornell University, New York, NY; and

6. Leukemia Service, Department of Medicine and

7. Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY

Abstract

Key Points Wt1 heterozygous loss enhanced stem cell self-renewal in an age-dependent manner. Wt1-haploinsufficient leukemias require additional events to promote hematopoietic transformation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/132/12/1265/1467666/blood837468.pdf

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