Comprehensive analysis of PTEN status in Sézary syndrome-Reference-Cited by-同舟云学术

Comprehensive analysis of PTEN status in Sézary syndrome

Published:2013-11-14 Issue:20 Volume:122 Page:3511-3520
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cristofoletti Cristina¹,Picchio Maria Cristina¹,Lazzeri Cristina¹²,Tocco Valeria¹,Pagani Elena¹,Bresin Antonella¹,Mancini Barbara¹,Passarelli Francesca¹,Facchiano Antonio¹,Scala Enrico¹,Lombardo Giuseppe Alfonso¹,Cantonetti Maria³,Caprini Elisabetta¹,Russo Giandomenico¹,Narducci Maria Grazia¹

Affiliation:

1. Istituto Dermopatico dell’Immacolata–Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy;

2. Department of Clinical Immunology, Sapienza University of Rome, Rome, Italy; and

3. Department of Hematology, University of Tor Vergata, Rome, Italy

Abstract

Key Points PTEN is downregulated in Sézary syndrome by different mechanisms, mostly by gene deletions and microRNAs. PTEN deficiency activates AKT in skin resident but not circulating Sezary cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/20/3511/1371998/3511.pdf

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