Comprehensive analysis of PTEN status in Sézary syndrome-Reference-Cited by-同舟云学术

Comprehensive analysis of PTEN status in Sézary syndrome

Published:2013-11-14 Issue:20 Volume:122 Page:3511-3520
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cristofoletti Cristina¹,Picchio Maria Cristina¹,Lazzeri Cristina¹²,Tocco Valeria¹,Pagani Elena¹,Bresin Antonella¹,Mancini Barbara¹,Passarelli Francesca¹,Facchiano Antonio¹,Scala Enrico¹,Lombardo Giuseppe Alfonso¹,Cantonetti Maria³,Caprini Elisabetta¹,Russo Giandomenico¹,Narducci Maria Grazia¹

Affiliation:

1. Istituto Dermopatico dell’Immacolata–Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy;

2. Department of Clinical Immunology, Sapienza University of Rome, Rome, Italy; and

3. Department of Hematology, University of Tor Vergata, Rome, Italy

Abstract

Key Points PTEN is downregulated in Sézary syndrome by different mechanisms, mostly by gene deletions and microRNAs. PTEN deficiency activates AKT in skin resident but not circulating Sezary cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/20/3511/1371998/3511.pdf

Reference50 articles.

1. Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC).;Olsen;Blood,2007

2. Mycosis fungoides and Sézary syndrome.;Hwang;Lancet,2008

3. Molecular cytogenetic characterization of Sézary syndrome.;Mao;Genes Chromosomes Cancer,2003

4. Novel and highly recurrent chromosomal alterations in Sézary syndrome.;Vermeer;Cancer Res,2008

5. Identification of key regions and genes important in the pathogenesis of sezary syndrome by combining genomic and expression microarrays.;Caprini;Cancer Res,2009

Cited by 45 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Pathological and molecular insights into intravenous leiomyomatosis: an integrative multi-omics study;2024-05-03

2. Progression of Mycosis Fungoides After Fingolimod Treatment for Multiple Sclerosis and Targeted Next-Generation Sequencing Demonstrating Potential Links Between the Two Diseases;JCO Precision Oncology;2023-02

3. Genetically Driven CD39 Expression Affects Sezary Cell Viability and IL-2 Production and Detects Two Patient Subsets with Distinct Prognosis;Journal of Investigative Dermatology;2022-11

4. miRNA Signature in Early-stage Mycosis Fungoides;Acta Dermato-Venereologica;2022-10-04

5. Combined High-Throughput Approaches Reveal the Signals Driven by Skin and Blood Environments and Define the Tumor Heterogeneity in Sézary Syndrome;Cancers;2022-06-09