Early response with dasatinib or imatinib in chronic myeloid leukemia: 3-year follow-up from a randomized phase 3 trial (DASISION)

Author:

Jabbour Elias1,Kantarjian Hagop M.1,Saglio Giuseppe2,Steegmann Juan Luis3,Shah Neil P.4,Boqué Concepción5,Chuah Charles6,Pavlovsky Carolina7,Mayer Jiří8,Cortes Jorge1,Baccarani Michele9,Kim Dong-Wook10,Bradley-Garelik M. Brigid11,Mohamed Hesham12,Wildgust Mark12,Hochhaus Andreas13

Affiliation:

1. The University of Texas MD Anderson Cancer Center, Houston, TX;

2. University of Torino, Ospedale San Luigi Gonzaga, Orbassano-Torino, Italy;

3. Hospital de la Princesa, Madrid, Spain;

4. University of California, San Francisco School of Medicine, San Francisco, CA;

5. Department of Clinical Hematology, Institut Català d’Oncologia, Hospitalet de Llobregat, Barcelona, Spain;

6. Singapore General Hospital and Duke-National University of Singapore Graduate Medical School, Singapore;

7. Fundación Para Combatir la Leucemia, Angelica Ocampo Hospitalization and Clinical Research Center, Buenos Aires, Argentina;

8. University Hospital Brno and Central European Institute of Technology Masaryk University, Brno, Czech Republic;

9. University of Bologna, Bologna, Italy;

10. The Catholic University of Korea, Seoul, Korea;

11. Bristol-Myers Squibb, Wallingford, CT;

12. Bristol-Myers Squibb, Princeton, NJ; and

13. Universitätsklinikum Jena, Jena, Germany

Abstract

Key Points In a 3-year follow-up of the DASatinib versus Imatinib Study In treatment-Naive CML patients trial, first-line dasatinib resulted in faster and deeper responses compared with imatinib. Deeper responses at 3, 6, and 12 months were associated with better 3-year progression-free survival and overall survival.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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