Perinucleolar relocalization and nucleolin as crucial events in the transcriptional activation of key genes in mantle cell lymphoma-Reference-Cited by-同舟云学术

Perinucleolar relocalization and nucleolin as crucial events in the transcriptional activation of key genes in mantle cell lymphoma

Published:2014-03-27 Issue:13 Volume:123 Page:2044-2053
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Allinne Jeanne¹,Pichugin Andrei¹²,Iarovaia Olga¹²³,Klibi Manel¹²,Barat Ana¹²,Zlotek-Zlotkiewicz Ewa¹,Markozashvili Diana¹²,Petrova Natalia²³,Camara-Clayette Valérie⁴⁵,Ioudinkova Elena¹²³,Wiels Joëlle¹²,Razin Sergey V.²³⁶,Ribrag Vincent⁴⁵,Lipinski Marc¹²,Vassetzky Yegor S.¹²

Affiliation:

1. Unité Mixte de Recherche 8126, Université Paris-Sud, National Centre for Scientific Research, Institut de Cancérologie Gustave Roussy, Villejuif, France;

2. LIA1066 Laboratoire Franco-Russe de Recherche en Oncologie, Villejuif, France;

3. Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia;

4. Institut de Recherche Intégrée en Cancérologie, Institut de Cancérologie Gustave Roussy, Villejuif, France;

5. Institut National de la Santé et de la Recherche Médicale unité (U) 1009, Université Paris Sud, Institut de Cancérologie Gustave Roussy, Villejuif, France; and

6. Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia

Abstract

Key Points We propose a novel oncogenic mechanism linked to the perinucleolar relocalization of chromosomal segments resulting from the translocation. MCL and BL translocations result in new Ccnd1 and c-myc nuclear positioning, respectively, and nucleolin-dependent activation in both cases.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/13/2044/1375050/2044.pdf

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