Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia-Reference-Cited by-同舟云学术

Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia

Published:2014-06-19 Issue:25 Volume:123 Page:3864-3872
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Suragani Rajasekhar N. V. S.¹,Cawley Sharon M.¹,Li Robert¹,Wallner Samantha¹,Alexander Mark J.¹,Mulivor Aaron W.¹,Gardenghi Sara²,Rivella Stefano²³,Grinberg Asya V.¹,Pearsall R. Scott¹,Kumar Ravindra¹

Affiliation:

1. Acceleron Pharma, Cambridge, MA; and

2. Department of Pediatrics, Division of Hematology-Oncology, and

3. Department of Cell and Development Biology, Weill Cornell Medical College, New York, NY

Abstract

Key Points Modified ActRIIB ligand trap promotes terminal erythroid differentiation and mitigates ineffective erythropoiesis in murine β-thalassemia. This agent reduces anemia, α-globin aggregates, hemolysis, and disease complications such as iron overload, splenomegaly, and bone defects.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/25/3864/1464271/3864.pdf

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