Affiliation:
1. From The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Vaccine Technology, Melbourne, Victoria, Australia
Abstract
AbstractAlthough previous studies had indicated that the CD8α- and CD8α+ subtypes of murine dendritic cells (DCs) differ in immediate origin, a recent study found that intravenous transfer of CD8α- DCs led to CD8α+ DCs in the spleen several days later, suggesting a direct precursor-product relationship. We have repeated these experiments with a balance sheet approach. We find that though a few CD8α+ DCs can be generated in such experiments, this is a rare event and could be the result of a contaminant precursor. Most of the immediate precursors of CD8α+ DCs are cells that lack the phenotype of a recognizable DC. CD8α- DCs and CD8α+ DCs are not precursor-product related, though these sublineages may be connected further upstream.
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Cited by
55 articles.
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