MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML-Reference-Cited by-同舟云学术

MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML

Published:2018-10-04 Issue:14 Volume:132 Page:1526-1534
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sanders Mathijs A.¹,Chew Edward²³⁴⁵,Flensburg Christoffer²⁴,Zeilemaker Annelieke¹,Miller Sarah E.²,al Hinai Adil S.¹⁶,Bajel Ashish³⁵,Luiken Bram¹,Rijken Melissa¹,Mclennan Tamara⁷,Hoogenboezem Remco M.¹,Kavelaars François G.¹,Fröhling Stefan⁸⁹¹⁰,Blewitt Marnie E.⁴⁷,Bindels Eric M.¹,Alexander Warren S.²⁴,Löwenberg Bob¹,Roberts Andrew W.²³⁴⁵,Valk Peter J. M.¹,Majewski Ian J.²⁴

Affiliation:

1. Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands;

2. Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia;

3. Clinical Hematology, Peter MacCallum Cancer Center, Royal Melbourne Hospital, Parkville, VIC, Australia;

4. Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC, Australia;

5. Victorian Comprehensive Cancer Centre, Parkville, VIC, Australia;

6. National Genetic Center, Royal Hospital, Ministry of Health, Muscat, Sultanate of Oman;

7. Division of Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia;

8. Division of Translational Oncology, National Center for Tumor Diseases Heidelberg and German Cancer Research Center, Heidelberg, Germany;

9. German Cancer Consortium, Heidelberg, Germany; and

10. Section for Personalized Oncology, Heidelberg University Hospital, Heidelberg, Germany

Abstract

Key Points The DNA glycosylase MBD4 acts as a safeguard against damage from 5mC deamination. Germ line MBD4 deficiency stimulates clonal hematopoiesis and guides the development of leukemia via recurrent mutations in DNMT3A.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/132/14/1526/1406959/blood852566.pdf

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