Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function-Reference-Cited by-同舟云学术

Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function

Published:2014-07-03 Issue:1 Volume:124 Page:142-150
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Liu Yang¹^ORCID,Kretz Colin A.²^ORCID,Maeder Morgan L.³,Richter Catherine E.¹,Tsao Philip¹,Vo Andy H.¹,Huarng Michael C.¹,Rode Thomas¹,Hu Zhilian¹,Mehra Rohit⁴,Olson Steven T.⁵,Joung J. Keith³⁶,Shavit Jordan A.¹⁷^ORCID

Affiliation:

1. Department of Pediatrics and

2. Life Sciences Institute, University of Michigan, Ann Arbor, MI;

3. Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA;

4. Department of Pathology, University of Michigan, Ann Arbor, MI;

5. Center for Molecular Biology of Oral Diseases, University of Illinois, Chicago, IL;

6. Department of Pathology, Harvard Medical School, Boston, MA; and

7. Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI

Abstract

Key Points Juvenile zebrafish tolerate widespread coagulopathy due to complete ablation of antithrombin III, but develop lethal thrombosis as adults. In vivo structure/function analysis of antithrombin III in zebrafish reveals limited roles for heparin-binding and anti-IXa/Xa activity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/1/142/1379231/142.pdf

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