Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition-Reference-Cited by-同舟云学术

Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition

Published:2015-01-08 Issue:2 Volume:125 Page:316-326
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sinha Subarna¹,Thomas Daniel²³⁴,Yu Linda²³⁴,Gentles Andrew J.⁵,Jung Namyoung⁶,Corces-Zimmerman M. Ryan²³⁴,Chan Steven M.²³⁴,Reinisch Andreas²³⁴,Feinberg Andrew P.⁶,Dill David L.¹,Majeti Ravindra²³⁴

Affiliation:

1. Department of Computer Science, Stanford University, Stanford, CA;

2. Division of Hematology, Department of Medicine,

3. Cancer Institute, and

4. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA;

5. Department of Radiology, Stanford University, Stanford, CA; and

6. Center for Epigenetics, Institute for Basic Biomedical Science, Johns Hopkins School of Medicine, Baltimore, MD

Abstract

Key Points Boolean implications are a useful computational algorithm to mine mutation-specific methylation relationships in large cancer data sets. Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML, and inhibition of EZH2 induces myeloid differentiation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/2/316/1385756/316.pdf

Reference39 articles.

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4. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia.;Yan;Nat Genet,2011

5. DNMT3A mutations in acute myeloid leukemia.;Ley;N Engl J Med,2010

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