Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism-Reference-Cited by-同舟云学术

Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism

Published:2014-09-18 Issue:12 Volume:124 Page:1957-1967
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Delaney Michael Keegan¹,Liu Junling²,Kim Kyungho¹,Shen Bo¹,Stojanovic-Terpo Aleksandra¹,Zheng Yi³,Cho Jaehyung¹,Du Xiaoping¹

Affiliation:

1. Department of Pharmacology, University of Illinois at Chicago, Chicago, IL;

2. Institute of Medical Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China; and

3. Division of Experimental Hematology, Cincinnati Children’s Research Foundation, University of Cincinnati, Cincinnati, OH

Abstract

Key Points Physiological shear induces membrane scrambling and microvesiculation in agonist-stimulated platelets. Rac1 plays a general role in the platelet procoagulant response to shear and is important for coagulation in vitro and in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/12/1957/1380315/1957.pdf

Reference44 articles.

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5. Calcium involvement in aminophospholipid exposure and microparticle formation during platelet activation: a study using Ca2+-ATPase inhibitors.;Dachary-Prigent;Biochemistry,1995

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