Abnormally differentiated CD4+ or CD8+ T cells with phenotypic and genetic features of double negative T cells in human Fas deficiency

Author:

Rensing-Ehl Anne1,Völkl Simon2,Speckmann Carsten13,Lorenz Myriam Ricarda4,Ritter Julia5,Janda Ales13,Abinun Mario67,Pircher Hanspeter8,Bengsch Bertram19,Thimme Robert19,Fuchs Ilka1,Ammann Sandra1,Allgäuer Andrea2,Kentouche Karim10,Cant Andrew67,Hambleton Sophie67,Bettoni da Cunha Claudia11,Huetker Sebastian12,Kühnle Ingrid12,Pekrun Arnulf13,Seidel Markus G.14,Hummel Michael5,Mackensen Andreas2,Schwarz Klaus1415,Ehl Stephan13

Affiliation:

1. Center for Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, Freiburg, Germany;

2. Department of Internal Medicine 5, Haematology and Oncology, University Hospital Erlangen, Erlangen, Germany;

3. Center for Paediatrics and Adolescent Medicine, University Medical Center, University of Freiburg, Freiburg, Germany;

4. Institute for Transfusion Medicine, University of Ulm, Ulm, Germany;

5. Institute of Pathology, Charité – University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany;

6. Department of Paediatric Immunology, Great North Children's Hospital, Newcastle upon Tyne, United Kingdom;

7. Institute of Cellular Immunology, Newcastle University, Newcastle upon Tyne, United Kingdom;

8. Institute of Immunology, Department of Medicine Microbiology and Hygiene, and

9. Department of Internal Medicine II, University Medical Center Freiburg, Freiburg, Germany;

10. Department of Paediatrics, Jena University Hospital, Jena, Germany;

11. Department of Pediatric Hematology and Oncology, Hannover Medical School, Hanover Hannover, Germany;

12. Division of Pediatric Haematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Göttingen, Göttingen, Germany;

13. Department of Paediatric Haematology/Oncology, University Medical Center Bremen, Bremen, Germany,

14. Paediatric Haematology-Oncology, Medical University of Graz, Graz, Austria; and

15. Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service, Ulm, Germany

Abstract

Key Points Lack of KLRG1 and T-bet expression is a unique feature of DNT and subsets of single positive T cells in ALPS patients. Genetic, phenotypic, and transcriptional evidence indicates that DNT in ALPS patients derive from both CD4+ and CD8+ T cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3