Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity

Author:

Lee-Chang Catalina1,Bodogai Monica1,Moritoh Kanako1,Olkhanud Purevdorj B.1,Chan Andrew C.2,Croft Michael3,Mattison Julie A.4,Holst Peter Johannes5,Gress Ronald E.6,Ferrucci Luigi7,Hakim Fran6,Biragyn Arya1

Affiliation:

1. Immunoregulation Section, Laboratory of Molecular Biology and Immunology, Baltimore, MD;

2. Department of Immunology, Genentech, Inc., South San Francisco, CA;

3. Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA;

4. The Nonhuman Primate Core Facility, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD;

5. Laboratory of Experimental Vaccinology, Department of International Health, Immunology and Microbiology, University of Copenhagen, Denmark;

6. Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD; and

7. Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD.

Abstract

Key Points We report the discovery of evolutionary conserved aging-associated accumulation of 4-1BBL+ B cells that induce GrB+ CD8+ T cells. This discovery explains paradoxical retarded tumor growth in the elderly.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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